Hurdle, Julian: search on Z-Library

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1

New β-lactam – tetramic acid hybrids show promising antibacterial activities

Cherian, Philip T., Cheramie, Martin N., Marreddy, Ravi K.R., Hurdle, Julian G., Lee, Richard E.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2018

Language:

english

File:

PDF, 964 KB

english, 2018

2

Pharmacophore Modeling, Synthesis, and Antibacterial Evaluation of Chalcones and Derivatives

Zhang, Mingming, Prior, Allan M., Maddox, Marcus M., Shen, Wan-Jou, Hevener, Kirk E., Bruhn, David F., Lee, Robin B., Singh, Aman P., Reinicke, Justin, Simmons, Charles J., Hurdle, Julian G., Lee, Ric

Journal:

Year:

2018

Language:

english

File:

PDF, 2.68 MB

english, 2018

3

Syntheses and evaluation of macrocyclic engelhardione analogs as antitubercular and antibacterial agents

Shen, Li, M Maddox, Marcus, Adhikari, Sudip, Bruhn, David F, Kumar, Manish, Lee, Robin E, Hurdle, Julian G, Lee, Richard E, Sun, Dianqing

Journal:

The Journal of Antibiotics

Year:

2013

Language:

english

File:

PDF, 425 KB

english, 2013

4

NF-κB inhibitors, unique γ-pyranol-γ-lactams with sulfide and sulfoxide moieties from Hawaiian plant Lycopodiella cernua derived fungus Paraphaeosphaeria neglecta FT462

Li, Chun-Shun, Sarotti, Ariel M., Huang, Peng, Dang, Uyen T., Hurdle, Julian G., Kondratyuk, Tamara P., Pezzuto, John M., Turkson, James, Cao, Shugeng

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 2.41 MB

english, 2017

5

A simple in vitro PK/PD model system to determine time–kill curves of drugs against Mycobacteria

Nageshwar R. Budha, Robin B. Lee, Julian G. Hurdle, Richard E. Lee, Bernd Meibohm

Journal:

Year:

2009

Language:

english

File:

PDF, 473 KB

english, 2009

6

Chemical Modulation of the Biological Activity of Reutericyclin: a Membrane-Active Antibiotic from Lactobacillus reuteri

Cherian, Philip T., Wu, Xiaoqian, Maddox, Marcus M., Singh, Aman P., Lee, Richard E., Hurdle, Julian G.

Journal:

Scientific Reports

Year:

2014

Language:

english

File:

PDF, 1.45 MB

english, 2014

7

Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux

Lee, Richard E, Hurdle, Julian G, Liu, Jiuyu, Bruhn, David F, Matt, Tanja, Scherman, Michael S, Vaddady, Pavan K, Zheng, Zhong, Qi, Jianjun, Akbergenov, Rashid, Das, Sourav, Madhura, Dora B, Rathi, Ch

Journal:

Nature Medicine

Year:

2014

Language:

english

File:

PDF, 1.20 MB

english, 2014

8

Novel Acyl Phosphate Mimics that Target PlsY, an Essential Acyltransferase in Gram-Positive Bacteria

Kimberly D. Grimes, Ying-Jie Lu, Yong-Mei Zhang, Vicki A. Luna, Julian G. Hurdle, Elizabeth I. Carson, Jianjun Qi, Sucheta Kudrimoti, Charles O. Rock, Richard E. Lee

Journal:

Year:

2008

Language:

english

File:

PDF, 297 KB

english, 2008

9

Constitutive expression of the cryptic vanGCd operon promotes vancomycin resistance in Clostridioides difficile clinical isolates

Shen, Wan-Jou, Deshpande, Aditi, Hevener, Kirk E, Endres, Bradley T, Garey, Kevin W, Palmer, Kelli L, Hurdle, Julian G

Journal:

Journal of Antimicrobial Chemotherapy

Year:

2019

File:

PDF, 811 KB

2019

10

Action of nitroheterocyclic drugs against Clostridium difficile

Kumar, Manish, Adhikari, Sudip, Hurdle, Julian G.

Journal:

International Journal of Antimicrobial Agents

Year:

2014

Language:

english

File:

PDF, 745 KB

english, 2014

11

Frizzled proteins are colonic epithelial receptors for C. difficile toxin B

Tao, Liang, Zhang, Jie, Meraner, Paul, Tovaglieri, Alessio, Wu, Xiaoqian, Gerhard, Ralf, Zhang, Xinjun, Stallcup, William B., Miao, Ji, He, Xi, Hurdle, Julian G., Breault, David T., Brass, Abraham L.,

Journal:

Year:

2016

Language:

english

File:

PDF, 21.11 MB

english, 2016

12

N-Substituted 3-Acetyltetramic Acid Derivatives as Antibacterial Agents

Yendapally, Raghunandan, Hurdle, Julian G., Carson, Elizabeth I., Lee, Robin B., Lee, Richard E.

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 139 KB

english, 2008

13

Design, synthesis and microbiological evaluation of ampicillin–tetramic acid hybrid antibiotics

Cherian, Philip T, Deshpande, Aditi, Cheramie, Martin N, Bruhn, David F, Hurdle, Julian G, Lee, Richard E

Journal:

The Journal of Antibiotics

Year:

2016

Language:

english

File:

PDF, 832 KB

english, 2016

14

Pentacyclic Nitrofurans with In Vivo Efficacy and Activity against Nonreplicating Mycobacterium tuberculosis

Rakesh,, Bruhn, David F., Scherman, Michael S., Woolhiser, Lisa K., Madhura, Dora B., Maddox, Marcus M., Singh, Aman P., Lee, Robin B., Hurdle, Julian G., McNeil, Michael R., Lenaerts, Anne J., Meibo

Journal:

Year:

2014

Language:

english

File:

PDF, 374 KB

english, 2014

15

The Fatty Acid Synthesis Protein Enoyl-ACP Reductase II (FabK) is a Target for Narrow-Spectrum Antibacterials for Clostridium difficile Infection

Marreddy, RaviKanthReddy, Wu, Xiaoqian, Madhab, Sapkota, Prior, Allan M., Jones, Jesse, Sun, Dianqing, Hevener, Kirk E., Hurdle, Julian G.

Journal:

ACS Infectious Diseases

Year:

2018

Language:

english

File:

PDF, 678 KB

english, 2018

16

Constitutive expression of the cryptic vanGCd operon promotes vancomycin resistance in Clostridioides difficile clinical isolates

Shen, Wan-Jou, Deshpande, Aditi, Hevener, Kirk E, Endres, Bradley T, Garey, Kevin W, Palmer, Kelli L, Hurdle, Julian G

Journal:

Journal of Antimicrobial Chemotherapy

Year:

2019

Language:

english

File:

PDF, 811 KB

english, 2019

17

Rifamycin Resistance in Clostridium difficile is Generally Associated with a Low Fitness Burden

Dang, Uyen T., Zamora, Idalia, Hevener, Kirk E., Adhikari, Sudip, Wu, Xiaoqian, Hurdle, Julian G.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2016

Language:

english

File:

PDF, 1022 KB

english, 2016

18

840. Clinical Failure Rates Associated with Hemin-induced Metronidazole Resistance in Clostridioides difficile

Gonzales-Luna, Anne J, Shen, Wan-Jou, Deshpande, Aditi, Dotson, Kierra M, Lancaster, Chris, Hurdle, Julian, Garey, Kevin W

Journal:

Open Forum Infectious Diseases

Year:

2019

Language:

english

File:

PDF, 290 KB

english, 2019

19

The structure–activity relationship of urea derivatives as anti-tuberculosis agents

Joshua R. Brown, Elton J. North, Julian G. Hurdle, Christophe Morisseau, Jerrod S. Scarborough, Dianqing Sun, Jana Korduláková, Michael S. Scherman, Victoria Jones, Anna Grzegorzewicz, Rebecca M. Crew

Journal:

Bioorganic & Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 2.13 MB

english, 2011

20

The Clostridium difficile proline racemase is not essential for early logarithmic growth and infection

Wu, Xiaoqian, Hurdle, Julian G.

Journal:

Canadian Journal of Microbiology

Year:

2014

File:

PDF, 474 KB

2014

21

Small-molecule inhibition of the C. difficile FAS-II enzyme, FabK, results in selective activity

Jones, Jesse A., Prior, Allan M., Marreddy, Ravi K. R., Wahrmund, Rebecca D., Hurdle, Julian G., Sun, Dianqing, Hevener, Kirk E.

Journal:

ACS Chemical Biology

Year:

2019

File:

PDF, 1.17 MB

2019

22

Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections

Hurdle, Julian G., O'Neill, Alex J., Chopra, Ian, Lee, Richard E.

Journal:

Nature Reviews Microbiology

Year:

2011

Language:

english

File:

PDF, 494 KB

english, 2011

23

Secondary metabolites from Bacillus amyloliquefaciens isolated from soil can kill Burkholderia pseudomallei

Boottanun, Patcharaporn, Potisap, Chotima, Hurdle, Julian G., Sermswan, Rasana W.

Journal:

Year:

2017

Language:

english

File:

PDF, 1.64 MB

english, 2017

24

Mode of Action and Bactericidal Properties of Surotomycin against Growing and Non-growing Clostridium difficile

Alam, Md. Zahidul, Wu, Xiaoqian, Mascio, Carmela, Chesnel, Laurent, Hurdle, Julian G.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2015

Language:

english

File:

PDF, 742 KB

english, 2015

25

Bacterial persister cells tackled

Hurdle, Julian G., Deshpande, Aditi

Journal:

Year:

2018

Language:

english

File:

PDF, 203 KB

english, 2018

26

Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase

Hevener, Kirk E., Yun, Mi-Kyung, Qi, Jianjun, Kerr, Iain D., Babaoglu, Kerim, Hurdle, Julian G., Balakrishna, Kanya, White, Stephen W., Lee, Richard E.

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 4.40 MB

english, 2010

27

The early stage peptidoglycan biosynthesis Mur enzymes are antibacterial and antisporulation drug targets for recurrent Clostridioides difficile infection

Sapkota, Madhab, Marreddy, Ravi K.R., Wu, Xiaoqian, Kumar, Manish, Hurdle, Julian G.

Journal:

Year:

2019

File:

PDF, 1.54 MB

2019

28

Screening for a Diamond in the Rough

Wu, Xiaoqian, Hurdle, Julian G.

Journal:

Chemistry & Biology

Year:

2013

Language:

english

File:

PDF, 348 KB

english, 2013

29

Discovery, synthesis, and biological evaluation of piperidinol analogs with anti-tuberculosis activity

Dianqing Sun, Michael S. Scherman, Victoria Jones, Julian G. Hurdle, Lisa K. Woolhiser, Susan E. Knudson, Anne J. Lenaerts, Richard A. Slayden, Michael R. McNeil, Richard E. Lee

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 631 KB

english, 2009

30

Evaluation of Flavonoid and Resveratrol Chemical Libraries Reveals Abyssinone II as a Promising Antibacterial Lead

Prof. Dianqing Sun, Prof. Julian G. Hurdle, Robin Lee, Prof. Richard Lee, Prof. Mark Cushman, Prof. John M. Pezzuto

Journal:

Year:

2012

Language:

english

File:

PDF, 490 KB

english, 2012

31

Progress in the Discovery of Treatments for C. difficile Infection: A Clinical and Medicinal Chemistry Review

Tsutsumi, Lissa, Owusu, Yaw, Hurdle, Julian, Sun, Dianqing

Journal:

Current Topics in Medicinal Chemistry

Year:

2013

File:

PDF, 466 KB

2013

32

Chromosomal Resistance to Metronidazole in Clostridioides difficile can be Mediated by Epistasis Between Iron Homeostasis and Oxidoreductases

Deshpande, Aditi, Wu, Xiaoqian, Huo, Wenwen, Palmer, Kelli L., Hurdle, Julian G.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2020

File:

PDF, 9.62 MB

2020

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